Beneath, behind, besides and beyond evidence based medicine.

It appears that the initial resistance/scepticism towards evidence-based medicine (EBM) has declined and the current challenge for professionals is “how to” rather than “why to” practice EBM. The major hurdles include limitations related to: (i) availability (of high quality evidence on problems/ interventions relevant to our setting), (ii) accessibility (to current evidence at the point-ofcare), (iii) appraisal (of available evidence to judge reliability/validity), and (iv) applicability (of evidence developed for/from another setting into the local setting). The sterling contribution of the Cochrane Collaboration worldwide and the South Asian Cochrane Network (now Centre) in India have greatly facilitated progress towards overcoming these barriers.